Eligibility: 439375ef42cecd8367ae26538eddc91c [RDF]
| Label | 439375ef42cecd8367ae26538eddc91c |
|---|---|
| Slug | 439375ef42cecd8367ae26538eddc91c |
| Criteria | DISEASE CHARACTERISTICS: Age 50 to 75 years: Not eligible for autologous transplantation OR Failed prior autologous transplantation Non-Hodgkin's lymphoma (NHL) or chronic lymphocytic leukemia (CLL) Failed prior therapy with alkylating agent and/or fludarabine Multiple myeloma Stage II or III disease Received prior chemotherapy Under 50 years considered on case by case basis: NHL, CLL, or multiple myeloma at high risk of regimen related toxicity Under 75 years with other hematologic malignancies: Treatable by allogeneic bone marrow transplant High risk for regimen related toxicity using standard dose regimens Autografting contraindicated Myelodysplastic syndromes Myeloproliferative syndromes Acute leukemia in remission Chronic myelogenous leukemia in second chronic phase Hodgkin's disease No rapidly progressive, high grade NHL HLA genotypically identical sibling donor No CNS involvement A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 50 to 75 Performance status: Karnofsky 50-100% (>70% if older than 65) Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Bilirubin no greater than 2 times upper limit of normal (ULN) SGOT and SGPT less than 4 times ULN Renal: Creatinine clearance at least 50 mL/min Cardiovascular: No cardiac failure requiring therapy Cardiac ejection fraction at least 40% No poorly controlled hypertension Pulmonary: No severe defects in pulmonary function testing No supplementary continuous oxygen Other: Not pregnant Fertile patients must use adequate contraception during and for 12 months after therapy Donor Characteristics: 12 to 75 years HLA genotypically identical sibling Not identical twin Adequate veins for leukopheresis or agree to central venous catheter Not pregnant HIV negative No allergy to filgrastim (G-CSF) No current serious systemic illness PRIOR CONCURRENT THERAPY: See Disease Characteristics |
| Maximum age | 75 Years |
| Healthy volunteers | No |
| Study pop | |
| Minimum age | 50 Years |
| Gender | Both |
| Sampling method | |
| Provenances | http://clinicaltrials.gov/show/NCT00003196?displayxml=true |
| Similars | None |
| Interlinks | None |
